Symbol
Name
ID

Notch2
notch 2
MGI:97364

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Atrial septal defect	Ventricular septal defect	Tetralogy of Fallot	Coarctation of aorta	Peripheral pulmonary artery stenosis	Patent ductus arteriosus	Renal artery stenosis	Stroke	Pulmonic stenosis	Hypertension	Telangiectasia of the skin
Disease(s) Associated with NOTCH2	Atrial septal defect	Ventricular septal defect	Tetralogy of Fallot	Coarctation of aorta	Peripheral pulmonary artery stenosis	Patent ductus arteriosus	Renal artery stenosis	Stroke	Pulmonic stenosis	Hypertension	Telangiectasia of the skin
Alagille syndrome
Hajdu-Cheney syndrome

Mouse Phenotypes

pulmonary artery stenosis

supravalvar pulmonary trunk stenosis

aorta stenosis

abnormal glomerular capillary endothelium morphology

abnormal hyaloid artery morphology

abnormal kidney vasculature morphology

kidney microaneurysm

abnormal placenta vasculature

abnormal vascular smooth muscle morphology

abnormal myocardial trabeculae morphology

heart hypoplasia

pericardial edema

pericardial effusion

abnormal cardiovascular system physiology

abnormal blood flow velocity

hemorrhage

ovary hemorrhage

kidney hemorrhage

Availability

Mouse Genotype

Notch2^tm1Grid/Notch2^tm1Grid

Notch2^tm1Yha/Notch2^tm1Yha

Notch2^tm2Grid/Notch2^tm2Grid

Notch2^tm3.1Grid/Notch2^tm3.1Grid

Notch2^tm3Grid/Notch2^tm3Grid
Tg(Pax3-cre)1Joe/0 (conditional)

Notch2^tm3Grid/Notch2^tm3Grid
Tg(Tpbpa-cre,-EGFP)5Jcc/0 (conditional)

Notch2^tm3Grid/Notch2^tm3.1Grid
Tg(Tagln-cre)1Her/? (conditional)

Notch2^tm3Grid/Notch2^tm3.1Grid
Pax3^tm1(cre)Joe/Pax3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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